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The data in the two tables beneath are estimates of adverse response incidence among the adult patients who participated in:
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Xanax Description
Xanax contains alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds.
The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-α] [1,4] benzodiazepine.
The structural formula is:
Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH.
Each Xanax tablet, for oral administration, contains 0.25 mg, 0.5 mg, 1 mg, or 2 mg of alprazolam.
Inactive ingredients: cellulose, corn starch, docusate sodium, lactose, magnesium stearate, silicon dioxide and sodium benzoate. In addition, the 0.5 mg tablet contains FD&C Yellow №6 and the 1 mg tablet contains FD&C Blue №2.
Xanax Medication Guide
Xanax (ZAN-aks)
(alprazolam) tablets, C-IV
What is the most important information I should know about Xanax?
Xanax is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system (CNS) depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma and death. Get emergency help right away if any of the following happens:
o shallow or slowed breathing
o breathing stops (which may lead to the heart stopping)
o excessive sleepiness (sedation)
Do not drive or operate heavy machinery until you know how taking Xanax with opioids affects you.
Risk of abuse, misuse, and addiction. There is a risk of abuse, misuse, and addiction with benzodiazepines, including Xanax, which can lead to overdose and serious side effects including coma and death.
o Serious side effects including coma and death have happened in people who have abused or misused benzodiazepines, including Xanax. These serious side effects may also include delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects.
o You can develop an addiction even if you take Xanax as prescribed by your healthcare provider.
o Take Xanax exactly as your healthcare provider prescribed.
o Do not share your Xanax with other people.
o Keep Xanax in a safe place and away from children.
Physical dependence and withdrawal reactions. Xanax can cause physical dependence and withdrawal reactions.
o Do not suddenly stop taking Xanax. Stopping Xanax suddenly can cause serious and life-threatening side effects, including, unusual movements, responses, or expressions, seizures, sudden and severe mental or nervous system changes, depression, seeing or hearing things that others do not see or hear, an extreme increase in activity or talking, losing touch with reality, and suicidal thoughts or actions. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these symptoms.
o Some people who suddenly stop benzodiazepines, have symptoms that can last for several weeks to more than 12 months, including, anxiety, trouble remembering, learning, or concentrating, depression, problems sleeping, feeling like insects are crawling under your skin, weakness, shaking, muscle twitching, burning or prickling feeling in your hands, arms, legs or feet, and ringing in your ears.
o Physical dependence is not the same as drug addiction. Your healthcare provider can tell you more about the differences between physical dependence and drug addiction.
Do not take more Xanax than prescribed or take Xanax for longer than prescribed.
What is Xanax?
Xanax is a prescription medicine used:
o to treat anxiety disorders
o for the short-term relief of the symptoms of anxiety
o to treat panic disorder with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia)
Xanax is a federal controlled substance (C-IV) because it contains alprazolam that can be abused or lead to dependence. Keep Xanax in a safe place to prevent misuse and abuse. Selling or giving away Xanax may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines or street drugs.
It is not known if Xanax is safe and effective in children.
Elderly patients are especially susceptible to dose related adverse effects when taking Xanax.
It is not known if Xanax is safe and effective when used to treat anxiety disorder for longer than 4 months.
It is not known if Xanax is safe and effective when used to treat panic disorder for longer than 10 weeks.
Do not take Xanax if:
you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in Xanax. See the end of this Medication Guide for a complete list of ingredients in Xanax.
you are taking antifungal medicines including ketoconazole and itraconazole
Before you take Xanax, tell your healthcare provider about all of your medical conditions, including if you:
have or have had depression, mood problems, or suicidal thoughts or behavior
have liver or kidney problems
have lung disease or breathing problems
are pregnant or plan to become pregnant.
Taking Xanax late in pregnancy may cause your baby to have symptoms of sedation (breathing problems, sluggishness, low muscle tone), and/or withdrawal symptoms (jitteriness, irritability, restlessness, shaking, excessive crying, feeding problems).
Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with Xanax.
There is a pregnancy registry for women who take Xanax during pregnancy. The purpose of the registry is to collect information about the health of you and your baby. If you become pregnant during treatment with Xanax, talk to your healthcare provider about registering with the National Pregnancy Registry for Psychiatric Medications. You can register by calling 1–866–961–2388 or visiting https://womensmentalhealth.org/pregnancyregistry/.
are breastfeeding or plan to breastfeed. Xanax passes into your breast milk.
Talk to your healthcare provider about the best way to feed your baby if you take Xanax.
Breastfeeding is not recommended during treatment with Xanax.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Taking Xanax with certain other medicines can cause side effects or affect how well Xanax or the other medicines work. Do not start or stop other medicines without talking to your healthcare provider.
How should I take Xanax?
See “What is the most important information I should know about Xanax?”
Take Xanax exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Xanax to take and when to take it.
If you take too much Xanax, call your healthcare provider or go to the nearest hospital emergency room right away.
What are the possible side effects of Xanax?
Xanax may cause serious side effects, including:
See “What is the most important information I should know about Xanax?”
Seizures. Stopping Xanax can cause seizures and seizures that will not stop (status epilepticus).
Mania. Xanax may cause an increase in activity and talking (hypomania and mania) in people who have depression.
o Xanax can make you sleepy or dizzy and can slow your thinking and motor skills. Do not drive, operate heavy machinery, or do other dangerous activities until you know how Xanax affects you.
o Do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking Xanax without first talking to your healthcare provider. When taken with alcohol or drugs that cause sleepiness or dizziness, Xanax may make your sleepiness or dizziness much worse.
The most common side effects of Xanax include:
problems with coordination
hypotension
trouble saying words clearly (dysarthria)
changes in sex drive (libido)
These are not all the possible side effects of Xanax. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1–800-FDA-1088.
How should I store Xanax?
Store Xanax at room temperature between 68°F to 77°F (20°C to 25°C)
Keep Xanax and all medicines out of the reach of children.
General information about the safe and effective use of Xanax.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.
Do not use Xanax for a condition for which it was not prescribed.
Do not give Xanax to other people, even if they have the same symptoms that you have. It may harm them.
You can ask your pharmacist or healthcare xanax for sale cork provider for information about Xanax that is written for health professionals.
What are the ingredients in Xanax?
Active ingredient: alprazolam
Inactive ingredients: Cellulose, corn starch, docusate sodium, lactose, magnesium stearate, silicon dioxide and sodium benzoate. In addition, the 0.5 mg tablet contains FD&C Yellow №6 and the 1 mg tablet contains FD&C Blue №2.
Xanax® is a registered trademark of UPJOHN US 2 LLC, a Viatris Company.
For more information, call Viatris at 1–877–446–3679 (1–877–4-INFO-RX).
Distributed by:
Viatris Specialty LLC
Morgantown, WV 26505 U.S.A.
UPJ:MG:XNXT:RX2
Xanax Supply/Storage and Handling
Xanax is supplied in the following strengths and package configurations:
Xanax Tablets
Package Configuration
Tablet Strength (mg)
NDC
Print
Bottles of 100
Reverse Numbered
Unit dose (100)
Bottles of 500
Bottles of 1000
0.25 mg
NDC 0009–0029–01
NDC 0009–0029–46
NDC 0009–0029–02
NDC 0009–0029–14
white, oval, scored, imprinted
“Xanax 0.25”
Bottles of 100
Reverse Numbered
Unit dose (100)
Bottles of 500
Bottles of 1000
0.5 mg
NDC 0009–0055–01
NDC 0009–0055–46
NDC 0009–0055–03
NDC 0009–0055–15
peach, oval, scored, imprinted
“Xanax 0.5”
Bottles of 100
Bottles of 500
Bottles of 1000
1 mg
NDC 0009–0090–01
NDC 0009–0090–04
NDC 0009–0090–13
blue, oval, scored, imprinted
“Xanax 1.0”
Bottles of 100
Bottles of 500
2 mg
NDC 0009–0094–01
NDC 0009–0094–03
white, oblong, multi-scored, imprinted “Xanax” on one side and “2” on the reverse side
Xanax XR Supply/Storage and Handling
Xanax XR is supplied in the following strengths and package configurations:
Xanax XR Tablets
Package Configuration
Tablet Strength (mg)
NDC
Print
Bottles of 60
0.5 mg
NDC 0009–0057–07
white, pentagonal shaped tablets debossed with an “X” on one side and “0.5” on the other side
Bottles of 60
1 mg
NDC 0009–0059–07
yellow, square shaped tablets debossed with an “X” on one side and “1” on the other side
Bottles of 60
2 mg
NDC 0009–0066–07
blue, round shaped tablets debossed with an “X” on one side and “2” on the other side
Bottles of 60
3 mg
NDC 0009–0068–07
green, triangular shaped tablets debossed with an “X” on one side and “3” on the other side
Risks from Concomitant Xanax Use with Opioids
Concomitant use of Xanax, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate.
Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone. If a decision is made to prescribe Xanax concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. In patients already receiving an opioid analgesic, prescribe a lower initial dose of Xanax than indicated in the absence of an opioid and titrate based on clinical response. If an opioid is initiated in a patient already taking Xanax, prescribe a lower initial dose of the opioid and titrate based upon clinical response.
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Xanax Sale Postmarketing Experience
The following adverse reactions have been identified during postapproval use of Xanax. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Endocrine disorders: Hyperprolactinemia
General disorders and administration site conditions: Edema peripheral
Hepatobiliary disorders: Hepatitis, hepatic failure
Investigations: Liver enzyme elevations
Psychiatric disorders: Hypomania, mania
Reproductive system and breast disorders: Gynecomastia, galactorrhea
Skin and subcutaneous tissue disorders: Photosensitivity reaction, angioedema, Stevens-Johnson syndrome
Xanax Overdosage
Overdosage of benzodiazepines is characterized by central nervous system depression ranging from drowsiness to coma. In mild to moderate cases, symptoms can include drowsiness, confusion, dysarthria, lethargy, hypnotic state, diminished reflexes, ataxia, and hypotonia. Rarely, paradoxical or disinhibitory reactions (including agitation, irritability, impulsivity, violent behavior, confusion, restlessness, excitement, and talkativeness) may occur. In severe overdosage cases, patients may develop respiratory depression and coma. Overdosage of benzodiazepines in combination with other CNS depressants (including alcohol and opioids) may be fatal. Markedly abnormal (lowered or elevated) blood pressure, heart rate, or respiratory rate raise the concern that additional drugs and/or alcohol are involved in the overdosage.
In managing benzodiazepine overdosage, employ general supportive measures, including intravenous fluids and airway management. Flumazenil, a specific benzodiazepine receptor antagonist indicated for the complete or partial reversal of the sedative effects of benzodiazepines in the management of benzodiazepine overdosage, can lead to withdrawal and adverse reactions, including seizures, particularly in the context of mixed overdosage with drugs that increase seizure risk (e.g., tricyclic and tetracyclic antidepressants) and in patients with long-term benzodiazepine use and physical dependency. The risk of withdrawal seizures with flumazenil use may be increased in patients with epilepsy. Flumazenil is contraindicated in patients who have received a benzodiazepine for is it illegal to take xanax control of a potentially life-threatening condition (e.g., status epilepticus). xanax toronto If the decision is made to use flumazenil, it should be used as an adjunct to, not as a substitute for, supportive management of benzodiazepine overdosage. See the flumazenil injection Prescribing Information before use.
Xanax Drug Interactions
Drugs Having Clinically Important Interactions with Xanax
Opioids
Clinical implication
The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at gamma-aminobutyric acid (GABAA) sites and opioids interact primarily at mu receptors. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid‑related respiratory depression exists.
Prevention or management
Limit dosage and duration of concomitant use of Xanax and opioids, and monitor patients closely for respiratory depression and sedation.
Examples
Morphine, buprenorphine, hydromorphone, oxymorphone, oxycodone, fentanyl, methadone, alfentanil, butorphanol, codeine, dihydrocodeine, meperidine, pentazocine, remifentanil, sufentanil, tapentadol, tramadol.
CNS Depressants
Clinical implication
The benzodiazepines, including alprazolam, produce xanax for sale in ireland additive CNS depressant effects when coadministered with other CNS depressants.
Prevention or management
Limit dosage and duration of Xanax during concomitant use with CNS depressants.
Examples
Psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression.
Strong Inhibitors of CYP3A (except ritonavir)
Clinical implication
Concomitant use of Xanax with strong CYP3A inhibitors has a profound effect on the clearance of alprazolam, resulting in increased concentrations of alprazolam and increased risk of adverse reactions.
Prevention or management
Concomitant use of Xanax with a strong CYP3A4 inhibitor (except ritonavir) is contraindicated.
Examples
Ketoconazole, itraconazole, clarithromycin
Moderate or Weak Inhibitors of CYP3A
Clinical implication
Concomitant use of Xanax with CYP3A inhibitors may increase the concentrations of Xanax, resulting in increased risk of adverse reactions of alprazolam.
Prevention or management
Avoid use and consider appropriate dose reduction when Xanax is coadministered with a moderate or weak CYP3A inhibitor.
Examples
Nefazodone, fluvoxamine, cimetidine, erythromycin
CYP3A Inducers
Clinical implication
Concomitant use of CYP3A inducers can increase alprazolam metabolism and therefore can decease plasma levels of alprazolam.
Prevention or management
Caution is recommended during coadministration with Xanax.
Examples
Carbamazepine, phenytoin
Ritonavir
Clinical implication
Interactions involving ritonavir and alprazolam are complex and time dependent. Short term administration of ritonavir increased alprazolam exposure due to CYP3A4 inhibition. Following long term treatment of ritonavir (>10 to 14 days), CYP3A4 induction offsets this inhibition.
Alprazolam exposure was not meaningfully affected in the presence of ritonavir.
Prevention or management
Reduce Xanax dosage when ritonavir and Xanax are initiated concomitantly, or when ritonavir is added to a regimen where Xanax is stabilized.
Increase Xanax dosage to the target dosage after 10 to 14 days of dosing ritonavir and Xanax concomitantly. No dosage adjustment of Xanax is necessary in patients receiving ritonavir for more than 10 to14 days.
Concomitant use of Xanax with a strong CYP3A inhibitor, except ritonavir, is contraindicated.
Digoxin
Clinical implication
Increased digoxin concentrations have been reported when alprazolam was given, especially in geriatric patients (>65 years of age).
Prevention or management
In patients on digoxin therapy, measure serum digoxin concentrations before initiating Xanax. Continue monitoring digoxin serum concentration and toxicity frequently. Reduce the digoxin dose if necessary.
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Refunds Policy
If something isn’t right, we are happy to process a return. We believe in secure eCommerce and will provide a 30-day money back guarantee for the products and services that are bought online. All refund applications will be carefully considered and given at the discretion of Company Management. Please read through our policy below then follow the instructions.
Faulty or Incorrectly Sent Items
A refund can be processed in the following circumstances;
If an item is faulty,
Has been damaged in transit,
Does not perform in accordance with advertised claims or specification; and/or
Has been sent to you incorrectly.
We will pay for postage to return the goods in this instance and will either reship the correct item or arrange a refund.
Change of Mind
We will happily accept a return of a order for a refund or credit if you simply change your mind, on the following conditions:
The package is received in its original condition (has not been opened, used, damaged)
The package is NOT a pharmacy medicine/prescription, vitamin, baby formula, or adult product
The package has been ordered from our online pharmacy within the last 14 days
Postage is paid by the customer
Returns Process
In order to be eligible for the money back guarantee we must be notified within 30 days (or 14 for change of mind returns).
Please submit your return request form: This can be accessed once logged into your Pharmacy Direct customer account. Please navigate to My Account then select Order History click the Eye Icon to select the appropriate order. Then select the red/black arrow icon of the item for return. Complete the return request form. Once submitted our customer care team will be in touch within 24–48 hours with further details. Alternatively, you can contact our Customer Care Team directly by Email: [email protected].
If you are posting the goods back to us, please use the box your original order arrived in. We are unable to process a refund if any returned goods are damaged in transit.
Please use the correct return address, depending on the return type. We recommend using registered post as we do not take responsibility for lost, unregistered returns. (this will be advised by the Customer Care team member processing your return).
Please note: returns of ‘Special Orders’ will NOT be accepted. These include, but are not limited to: bulk quantities (considered greater than the average consumer quantities) and wholesaler purchases.
Delivery Policy
All orders are shipped 24/7 (Everyday). Please remember that all the packages are to be signed, so it’s advisable to ensure that you provide the correct details like your phone number and shipping address before you buy Xanax online from us.
Note: If your address is a P.O BOX, then you will be asked to collect the package from your local post office after you show proof of purchase.
What’s the delivery cost?
We charge $50 for express delivery, $75 for overnight delivery and $100 for international deliveries. There’s also an option for free delivery for US & Canada but this option only applies for orders higher $2000.
How to my track my order?
As soon as your placed order is shipped, we will send you an email along with the tracking details. You can click the tracking link which you received in the mail to check and track your package status anytime-anywhere. It is advised to check your spam folder, sometimes our emails end up there also.
Do I need to be present when you deliver?
Anyone can sign and receive your package on your behalf. Using our tracking mail, you might get the notification mail once it reaches the local post office. From there, you can schedule the delivery of your Xanax and pickup according to your convenience.
What’s the estimated time of delivery?
The typical ETA is
1–2 Days for US & Canada delivery
3 Days for express delivery
4–8 Days for international delivery
Do you offer overnight shipping of medications?
Yes, we offer overnight delivery via multiple courier agencies for all of our products.
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